zantac is contraindicated in patients with a history of hypersensitivity to it. In such cases, the drug should be discontinued immediately and appropriate therapy instituted, if available. If not, other drugs can be tried that may have less potential for causing an allergic reaction (e.g., amoxicillin) or bismuth subsalicylate tablets can sometimes help decrease systemic absorption of poorly absorbed medications (e.g., aspirin). Zantac should not be given concurrently with erythromycin or clarithromycin because these antibiotics increase zantac metabolism by inhibiting certain phase I enzymes involved in the hepatic conversion process [see Drug Interactions]. Patients who are at risk for developing hypoglycemia when taking antidiabetic agents should avoid concomitant use unless supervised by a qualified physician [see Contraindications] .
What precautions should I take while using zantac?