Taking levofloxacin when you have a head injury, spinal cord injury, or seizure will cause the levofloxacin to be absorbed into your bloodstream faster than normal. You could get too much of it in your system. If this happens, call 911 right away for medical help.
Also take levofloxacin at least 1 hour before eating a meal if you are taking certain drugs called grapefruit alkaloids (grapefruit medicines) or rifampicin (Rifadin). Taking these drugs along with levofloxacin could make it harder for the drug to work. Talk with your doctor about which other medicines may interact with levaquin and how best to avoid them while also receiving effective treatment from this medication. These include: cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), famotidine (Pepcid), esomeprazole magnesium/clarithromycin combination tablets(Nexium) , omeprazole sodium/bismuth subsalicylate combination tablet(Prilosec OTC); lansoprazole; misoindazole; potassium-containing antacid preparations including alka-seltzer and frusemide; nefazodone; verapamil ; amiodarone ; cisapride ; erythromycin