The onset of action is rapid and the effect persists for several hours after administration. Peak serum concentrations occur in less than an hour; half-lives range from 1 to 4 hours (average 2 hours). Aciphex is excreted primarily by renal tubular secretion with some clearance via biliary secretion. Other routes of elimination include hepatic metabolism, and, to a small degree, into the systemic circulation as unchanged drug or metabolites. The plasma protein binding constants are 96% and 85%, respectively. The volume of distribution at steady state ranges from 0.4 to 0:6 L/kg (1:7–2:3), indicating extensive tissue accumulation (>80%). Acetylsalicylic acid has been reported to inhibit intestinal motility but not colonic peristalsis [see DOSAGE AND ADMINISTRATION]. When therapy is discontinued, clinical effects may persist for between 48 and 72 hours following last dose administration [see DOSAGE AND ADMINISTRATION].
What happens if I miss a dose? Take the missed dose as soon as you remember it unless it’s closer than 12 hours later in time – then take your next scheduled one once you have remembered your missing one! Don’t double up on doses though or there will be no chance that they will work anyway! If this occurs just call us immediately so we can do something about it!